48?ð? ?? ??γ?19 ????????? ?????? '??? ???'????
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https://sdx.ulag9.top
??? ???, ?????? ????????? ???????? ????? ?????? ???? ??? ????
??? ???, SARS-CoV-2 ????????? 48?ð? ??? ????????? ?????? ?????
???????? ??? ???(ivermectin)?? ??? ???? ???? ?????? ??γ?19?? 48?ð? ??? ????????? ?????? ???????.
?? ??? ????? ??γ?19?? ??????? SARS-CoV-2 ????????? ??????? ????? ?? '?κ????(?????? ??, in vitro)' ??濡?? 48?ð? ??? ?????????.
???????? ?????????(FDA) ???? ???? ??? ????? ???? ???? ?????? ????????? 5000?? ????? ?????? ??????? ???????? ???? ??????? ???? ?????? ???? ??? ????? ?????(repurposing) ??伺?? ???????.
?????? ?????? ??γ?19 ??????, ???? ??????? ????
?? ???? ??γ?19 ?????? 127?????? ??? ???? ?????? 1?????? ????? ?????????? ??γ?19 ??????? ??? ?? ????????? ?? ?????? ??????? ???.
??? ???????? ????? ??????????η???, HIV ????? ?????????+????????(????? ??????), ????????? ?λ縣?(????? ????)???? ?????? ??γ?19 ??????? ????????? ???? ??γ?19?? ????????? ????? ??????? ?????? ????.
??? ??? ?ξ???????????(Royal Melbourne Hospital)?? ?????? ?????? ??????(Victorian Infectious Diseases Reference Laboratory) Leon Caly ???????? ???? 3?? Antiviral Research?? ???? ?????? ?????? ???????? ?????? ??γ?19 ??????? ?? ???? ??????.
Caly ?????? "??? ????? ?κ???? ??濡?? ???????? ???????? ????? ???? ??? FDA?? ???????? ???????"?? "??? ????? ?????? 2?ð? ??? Vero-hSLAM ?????? ??????? 48?ð? ??? RNA ????????? ?? 5000?? ???? ?? ??? ?? ???? ??????? ??? ????? ?????? ??? ???"?? ??????.
??? ???????
??? ????? ????? ?????? ?????? ?????? ?? ???????. FDA ?? ????? ?????? ???????? ?????, ??(scabies), ???????(river blindness), ?м?????, ??????, ????? ?? ???????????? ???????.
??? ????? ???????? ?????? ????????? ??????(avermectin) ?? ?迭?? ?????.
??? ????? 1975?? ??? ????????? Satoshi Omura ?????? ??????? ?????? ?????????????????(Merck Institute for Therapeutic Research) William C. Campbell ?????? ???????.
????? 2015?? ???????? ???????? ????? ???θ? ?뺧 ???????л? ??????? ????? ?÷??.
Omura ?????? ??? ????? Streptomyces avermitilis ?????????? ????????? Campbell ?????? Omura?? ????? ???繰?κ??? ??? ????? ???????. ??? ?? ???? ?? ??????? ?????? ???? ???????? ??????? ???????.
??? ????? ?????? ???? ?????? ???????(endectocide)??, ???? ?? ??? ??????? ?????濡 ????? ?? ??? ????????. ???????? ???? ?????????? ?? 0.12 ????? ??????? ?? ?????? ????????? ?? 50????? ?????.
??? ??? ?? ??? ?????? ?????????
??? ????? 1981?? ??? ???????? ??????? ?????? ???????(WHO)?? ??? ???? ????(List of Essential Medicines)?? ??????. ???? ????? ???????? ???????. ???? ???????? ????, ???? ???, ???ĸ?, ??(lice) ?? ?????? ?????? ?? ?????????? ????? ??? ???? ???????.
???? ??? ??? ??? ?????? ?? ???? ?????????? ???(roundworm) ?? ????(whipworm)?? ??????? ???????? ?????? ??????? ???????.
??? ????? ???????? ??????? ?????? ?????????. ???? ??? ???????? ??????? ??? ???? ?????? ???????? ??? ????????? ?????? ???????? ??????? ???????? ????? ?????? ???? ???????.
???? ??? ???? ?????? ??????, ???? ???? ???????? ???? ??????? ???? ???´?.
???????? ??????? ??? ??????
??? ????? ?????????????, ????????, ???? ?? ??? ?????? ??????? ?? ???? ?????? ?? ???.
????? ??????? ?? ???? ????(University of Bonn) ???????? ???????? ???????? ?????????????(chikungunya virus)?? ??????? ?? ???? ?????????, ??? ??ζ???????? Brian D Foy ???????? ???????? 5?? ???? ???? ???????? ????? ??????? ??????.
ij???? ?긮????÷?????? ???????? ?? ??? ????? ?????? ??????? ???????? ????????? ????? ???? ??????. ???? ???? ??? ??????? ???????? ??? ????? ???? ?? ?? ??????????? ??????? ??? ??????? ??? ????? ???????? ??????.
??γ?19?? ?????? ??? ??????
??γ?19?? SARS-CoV-2 ????????? ???? ????? ???????????ı??? SARS-CoV?? ?????? ?????? ???????.
?????? SARS-CoV ????????? IMP??/??1?? ???? ?????? ?????? ?????´?. IMP??/??1?? SARS-CoV ???????ĸ??? ??????? ??????????? ???????????(nucleocytoplasmic shutting)?? ?????? ?? ?? ???? ?????. ??? ??????? ?????? ?? ????? ??????? ??? ?????? ??? ?? ???? ???? ??????.
?????? ??? ????? ???????????(nuclear transport inhibitory activity) ????? SARS-CoV-2?? ??????? ?? ???? Caly ???????? ???????. ??? ????? ?????? ???? ??????? ?????(nuclear import) ?? HIV-1 ?????? ??????? ?????? ??ε??.
???????? ??γ?19 ?????????? ?????? Australia/VIC01/2020 ??????? vERO/Hslam ?????? ????????? ?????????. ???? ??? ????? ???????.
?? ????, ??? ????? ?????? ?????? ?????? 24?ð? ??? RNA ????????? 93% ???????. ?? ?????????? ????????? 99.8% ???? ?????? ???????.
48?ð??? ?????? ???????? ???? ??? ??? ????? RNA ????????? 5000?? ?????. 72?ð? ?? ????????? ?? ??? ???????? ????. ?????? ?????? ???? ?????? ???????.
???????? "??? RNA ????????? ??????? IMP??/??1 ????? ???? ?????(nuclear import)??? ??????? ??????? ?????????ν? ???????? ??????? ?? ???? ?????? ??????"?? ?????.
????? ?? ????????
??? ????? ??? ?????? ???????? ???????? ??ο? ??? ?? ???. ?뷮?? ?????? ?????? ???? ??????? ???? ???ĸ??? ???? ?????????? ???? ??????? ?????? ???? ????????? ??? ?? ???.
???? ???? ??????? ??????, ????????, ?? ??????, ????????, ?????? ?????????, ???? ???? ???.
???? ?????????????? ??? ????? ???????? ???????? ??? "????????? ???????? ???? ???????? ???? ??????? ???????? ??????? ?? ??? ?????? ??????"?? ??????.
작성일 : 24-10-20 22:52
조회 : 931
